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Abstract

The diagnosis of multiple primary malignancy (MPM) is not uncommon. Nevertheless
synchronous MPM involving endometrium and lungs is an extremely unusual event.
We report a case of 54 years old female patient who presented with abnormal uterine
bleeding and was diagnosed as a case of fibroid uterus. She was incidentally found
to have a nodular mass in left lung in chest x-ray. Contrast Enhanced Magnetic
Resonance Imaging (CEMRI) and Whole body 18F-fluro deoxy glucose positron
emission tomography- computed tomography (18 F-FDG PET-CT) revealed two
distinct lesions- one in endometrium and another in left lung. Immunohistochemistry
and biopsy from the endometrium and lung lesion were suggestive of endometrioid
carcinoma and adenocarcinoma respectively.
Hence, the existence of two malignancies having different histopathologies at
anatomically distinct sites suggests the diagnosis of synchronous dual primary
malignancy involving the endometrium and the lung, which being a rare combination,
prompted us to report this case.
Hence, the possibility of multiple primary malignancies existence should always be
considered during pre-treatment evaluation.

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